Search results for "disease progression patterns"

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Pattern of progression in advanced hepatocellular carcinoma treated with ramucirumab

2020

Abstract Background & Aims Radiological progression patterns to first‐line sorafenib have been associated with post‐progression and overall survival in advanced hepatocellular carcinoma, but these associations remain unknown for therapies in second‐ and later‐line settings. This post hoc analysis of REACH and REACH‐2 examined outcomes by radiological progression patterns in the second‐line setting of patients with advanced hepatocellular carcinoma treated with ramucirumab or placebo. Methods Patients with advanced hepatocellular carcinoma, Child‐Pugh A and Eastern Cooperative Oncology Group Performance Status 0 or 1 with prior sorafenib were randomized to receive ramucirumab 8mg/kg or place…

OncologySorafenibLiver CancerMalemedicine.medical_specialtyCarcinoma HepatocellularramucirumabPopulationRadioteràpiaAntineoplastic AgentsPlaceboAntibodies Monoclonal HumanizedRamucirumabLesionCàncer de fetge03 medical and health sciencesbest supportive care0302 clinical medicineInternal medicinePost-hoc analysisMedicineHumanseducationdisease progression patternseducation.field_of_studyHepatologyRadiotherapybusiness.industryProportional hazards modelLiver NeoplasmsMiddle AgedSorafenibmedicine.diseaseTreatment Outcome030220 oncology & carcinogenesisHepatocellular carcinoma030211 gastroenterology & hepatologyOriginal Articlemedicine.symptombusinesspost‐progression survivalnew extrahepatic lesionLiver cancermedicine.drug

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PEPhysical Sciences and Engineering
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LSLife Sciences
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